Activity-controlled proteolytic cleavage at the synapse

Highlights • Activity-controlled synaptic peptidases cleave proteins at, and in the vicinity of, synapses. • Each peptidase exhibits a set of proteolytic target proteins of its own. • Several peptidases cooperate to regulate distinct aspects of synaptic long-term potentiation. • Neurotrypsin may enh...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2014-08, Vol.37 (8), p.413-423
Hauptverfasser:	Sonderegger, Peter, Matsumoto-Miyai, Kazumasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Extracellular Matrix - drug effects Extracellular Matrix - physiology Humans Membranes Nerve Net - drug effects Nerve Net - physiology Neurology Neurons Neurosciences Peptide Hydrolases - pharmacology Proteins Proteolysis - drug effects Synapses - drug effects Synapses - physiology
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Zusammenfassung:	Highlights • Activity-controlled synaptic peptidases cleave proteins at, and in the vicinity of, synapses. • Each peptidase exhibits a set of proteolytic target proteins of its own. • Several peptidases cooperate to regulate distinct aspects of synaptic long-term potentiation. • Neurotrypsin may enhance synaptogenesis at activated synapses.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2014.05.007