ACQUIRED DRUG RESISTANCE DURING INADEQUATE THERAPY IN A YOUNG CHILD WITH TUBERCULOSIS

Drug resistance in children with tuberculosis is usually primary (transmitted); however, resistance acquisition during treatment is possible. We describe a child with tuberculosis who acquired drug resistance while receiving directly observed but inadequate first-line therapy and the programmatic an...

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Veröffentlicht in:	The Pediatric infectious disease journal 2014-08, Vol.33 (8), p.883-885
Hauptverfasser:	GARCIA-PRATS, Anthony J, WILLEMSE, Marianne, SEIFART, Heiner I, JORDAAN, Annemie M, WERELY, Cedric J, DONALD, Peter R, SCHAAF, H. Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - administration & dosage Antitubercular Agents - pharmacology Bacterial diseases Biological and medical sciences Child, Preschool Drug Resistance, Multiple, Bacterial Human bacterial diseases Humans Infectious diseases Male Medical sciences Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology
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Zusammenfassung:	Drug resistance in children with tuberculosis is usually primary (transmitted); however, resistance acquisition during treatment is possible. We describe a child with tuberculosis who acquired drug resistance while receiving directly observed but inadequate first-line therapy and the programmatic and clinical factors that may have contributed to resistance acquisition.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000000336