Cholestasis as a liver protective factor in paracetamol acute overdose
1. 1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats. 2. 2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats. 3. 3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded fr...
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| Veröffentlicht in: | General pharmacology 1995-11, Vol.26 (7), p.1619-1624 |
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| container_issue | 7 |
| container_start_page | 1619 |
| container_title | General pharmacology |
| container_volume | 26 |
| creator | Acevedo, Cristina Bengochea, Laura Tchercansky, Daniel M. Ouviña, Graciela Perazzo, Juan C. Lago, Néstor Lemberg, Abraham Rubio, Modesto C. |
| description | 1.
1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats.
2.
2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats.
3.
3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol.
4.
4. These results indicate a decrease in paracetamol toxicity related to stagnant bile. |
| doi_str_mv | 10.1016/0306-3623(95)00061-5 |
| format | Article |
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1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats.
2.
2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats.
3.
3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol.
4.
4. These results indicate a decrease in paracetamol toxicity related to stagnant bile.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(95)00061-5</identifier><identifier>PMID: 8690256</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetaminophen - metabolism ; Acetaminophen - poisoning ; Analgesics, Non-Narcotic - metabolism ; Analgesics, Non-Narcotic - poisoning ; Animals ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury ; Cholestasis ; Cholestasis - chemically induced ; Drug intoxications. Doping ; Drug Overdose ; liver ; Liver - drug effects ; Liver Diseases - metabolism ; Male ; Medical sciences ; paracetamol ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar</subject><ispartof>General pharmacology, 1995-11, Vol.26 (7), p.1619-1624</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f613949a5a3e54626e3840d3496530a1de01a5639e312bdf29fe4c7e1edac7133</citedby><cites>FETCH-LOGICAL-c386t-f613949a5a3e54626e3840d3496530a1de01a5639e312bdf29fe4c7e1edac7133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2947655$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8690256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acevedo, Cristina</creatorcontrib><creatorcontrib>Bengochea, Laura</creatorcontrib><creatorcontrib>Tchercansky, Daniel M.</creatorcontrib><creatorcontrib>Ouviña, Graciela</creatorcontrib><creatorcontrib>Perazzo, Juan C.</creatorcontrib><creatorcontrib>Lago, Néstor</creatorcontrib><creatorcontrib>Lemberg, Abraham</creatorcontrib><creatorcontrib>Rubio, Modesto C.</creatorcontrib><title>Cholestasis as a liver protective factor in paracetamol acute overdose</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats.
2.
2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats.
3.
3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol.
4.
4. These results indicate a decrease in paracetamol toxicity related to stagnant bile.</description><subject>Acetaminophen - metabolism</subject><subject>Acetaminophen - poisoning</subject><subject>Analgesics, Non-Narcotic - metabolism</subject><subject>Analgesics, Non-Narcotic - poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Cholestasis</subject><subject>Cholestasis - chemically induced</subject><subject>Drug intoxications. Doping</subject><subject>Drug Overdose</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver Diseases - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>paracetamol</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUIOInpYzccm3VwEKX5BwYuewzQ7i5HdTU22Bf-9qS09CoEMzDMvLw8h55zdcsb1HZNMF1ILeW3UDWNM80IdkDGvpqZgjPNDMt4jx-Qkpa8MCSXEiIwqbfKox-Rp9hlaTAMknyjkR1u_xkiXMQzohjzTBtwQIvU9XUIEhwN0oaXgVgPSkNk6JDwlRw20Cc92_4R8PD2-z16K-dvz6-xhXjhZ6aFoNJemNKBAoiq10CirktWyNFpJBrxGxkFpaVBysagbYRos3RQ51uCmXMoJudrm5n7fq9zbdj45bFvoMayS5UoLxUyVwXILuhhSitjYZfQdxB_Lmd3osxs3duPGGmX_9FmVzy52-atFh_X-aOcr7y93e0gO2iZC73zaY8KUU602MfdbDLOLtcdok_PYO6x9zFZtHfz_PX4BPiyKlA</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Acevedo, Cristina</creator><creator>Bengochea, Laura</creator><creator>Tchercansky, Daniel M.</creator><creator>Ouviña, Graciela</creator><creator>Perazzo, Juan C.</creator><creator>Lago, Néstor</creator><creator>Lemberg, Abraham</creator><creator>Rubio, Modesto C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19951101</creationdate><title>Cholestasis as a liver protective factor in paracetamol acute overdose</title><author>Acevedo, Cristina ; Bengochea, Laura ; Tchercansky, Daniel M. ; Ouviña, Graciela ; Perazzo, Juan C. ; Lago, Néstor ; Lemberg, Abraham ; Rubio, Modesto C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f613949a5a3e54626e3840d3496530a1de01a5639e312bdf29fe4c7e1edac7133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acetaminophen - metabolism</topic><topic>Acetaminophen - poisoning</topic><topic>Analgesics, Non-Narcotic - metabolism</topic><topic>Analgesics, Non-Narcotic - poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Cholestasis</topic><topic>Cholestasis - chemically induced</topic><topic>Drug intoxications. Doping</topic><topic>Drug Overdose</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver Diseases - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>paracetamol</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>online_resources</toplevel><creatorcontrib>Acevedo, Cristina</creatorcontrib><creatorcontrib>Bengochea, Laura</creatorcontrib><creatorcontrib>Tchercansky, Daniel M.</creatorcontrib><creatorcontrib>Ouviña, Graciela</creatorcontrib><creatorcontrib>Perazzo, Juan C.</creatorcontrib><creatorcontrib>Lago, Néstor</creatorcontrib><creatorcontrib>Lemberg, Abraham</creatorcontrib><creatorcontrib>Rubio, Modesto C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acevedo, Cristina</au><au>Bengochea, Laura</au><au>Tchercansky, Daniel M.</au><au>Ouviña, Graciela</au><au>Perazzo, Juan C.</au><au>Lago, Néstor</au><au>Lemberg, Abraham</au><au>Rubio, Modesto C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholestasis as a liver protective factor in paracetamol acute overdose</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>26</volume><issue>7</issue><spage>1619</spage><epage>1624</epage><pages>1619-1624</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats.
2.
2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats.
3.
3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol.
4.
4. These results indicate a decrease in paracetamol toxicity related to stagnant bile.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8690256</pmid><doi>10.1016/0306-3623(95)00061-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | General pharmacology, 1995-11, Vol.26 (7), p.1619-1624 |
| issn | 0306-3623 1879-0011 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetaminophen - metabolism Acetaminophen - poisoning Analgesics, Non-Narcotic - metabolism Analgesics, Non-Narcotic - poisoning Animals Biological and medical sciences Chemical and Drug Induced Liver Injury Cholestasis Cholestasis - chemically induced Drug intoxications. Doping Drug Overdose liver Liver - drug effects Liver Diseases - metabolism Male Medical sciences paracetamol Pharmacology. Drug treatments Rats Rats, Wistar |
| title | Cholestasis as a liver protective factor in paracetamol acute overdose |
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