Cholestasis as a liver protective factor in paracetamol acute overdose

1. 1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats. 2. 2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats. 3. 3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded fr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	General pharmacology 1995-11, Vol.26 (7), p.1619-1624
Hauptverfasser:	Acevedo, Cristina, Bengochea, Laura, Tchercansky, Daniel M., Ouviña, Graciela, Perazzo, Juan C., Lago, Néstor, Lemberg, Abraham, Rubio, Modesto C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Acetaminophen - poisoning Analgesics, Non-Narcotic - metabolism Analgesics, Non-Narcotic - poisoning Animals Biological and medical sciences Chemical and Drug Induced Liver Injury Cholestasis Cholestasis - chemically induced Drug intoxications. Doping Drug Overdose liver Liver - drug effects Liver Diseases - metabolism Male Medical sciences paracetamol Pharmacology. Drug treatments Rats Rats, Wistar
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1. 1. The effect of paracetamol overdoses on its disposition was investigated in cholestatic rats. 2. 2. Paracetamol plasma concentration and hepatic accumulation decrease about 70–80% in cholestatic rats. 3. 3. Cholestatic rats intoxicated with paracetamol showed less hepatic damage as concluded from biochemical and histological findings. These data are correlated with liver and plasmatic paracetamol. 4. 4. These results indicate a decrease in paracetamol toxicity related to stagnant bile.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(95)00061-5