Identification of fibronectin binding sites in dermatopontin and their biological function

Highlights • We identify the interactive sites between dermatopontin and fibronectin. • The binding site in dermatopontin for fibronectin is DP-4 peptide. • DP-4 peptide is one of a partial synthetic peptide of dermatopontin. • DP-4 peptide activates fibronectin and enhances cell adhesion activity....

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Veröffentlicht in:	Journal of dermatological science 2014-10, Vol.76 (1), p.51-59
Hauptverfasser:	Kato, Aiko, Okamoto, Osamu, Wu, Weimin, Matsuo, Noritaka, Kumai, Jun, Yamada, Yuji, Katagiri, Fumihiko, Nomizu, Motoyoshi, Fujiwara, Sakuhei
Format:	Artikel
Sprache:	eng
Schlagworte:	Active peptide Animals Binding Sites Chondroitin Sulfate Proteoglycans - metabolism Dermatology Dermatopontin Elastin - metabolism Extracellular Matrix Proteins - metabolism Fibronectin Fibronectins - metabolism Gene Silencing Homeostasis Humans Integrin alpha5beta1 - metabolism Mice Microscopy, Fluorescence Protein Binding Reactive Oxygen Species - metabolism RNA, Small Interfering - metabolism Skin - metabolism Skin Aging Thiazoles - chemistry Ultraviolet Rays Wound healing
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Beschreibung
Zusammenfassung:	Highlights • We identify the interactive sites between dermatopontin and fibronectin. • The binding site in dermatopontin for fibronectin is DP-4 peptide. • DP-4 peptide is one of a partial synthetic peptide of dermatopontin. • DP-4 peptide activates fibronectin and enhances cell adhesion activity. • DP-4 peptide has potential to be used for a wound treatment.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2014.07.003