Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold

Highlights • We investigate the causes of unexpected depigmentation induced by rhododendrol. • Melanocyte damage is related to tyrosinase activity at a certain threshold. • Melanocytes with higher tyrosinase activity produce a toxic hydroxyl-rhododendrol. • Suppression of tyrosinase activity rescues...

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Veröffentlicht in:	Journal of dermatological science 2014-10, Vol.76 (1), p.16-24
Hauptverfasser:	Kasamatsu, Shinya, Hachiya, Akira, Nakamura, Shun, Yasuda, Yuka, Fujimori, Taketoshi, Takano, Kei, Moriwaki, Shigeru, Hase, Tadashi, Suzuki, Tamio, Matsunaga, Kayoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Bleaching Agents - chemistry Butanols - chemistry Cell Survival Depigmentation Dermatology Humans Hydroxyl-rhododendrol Hypopigmentation - metabolism Melanins - biosynthesis Melanocyte Melanocytes - cytology Melanocytes - drug effects Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - chemistry Monophenol Monooxygenase - metabolism Rhododendrol RNA, Small Interfering - metabolism Skin - metabolism Skin Pigmentation - drug effects Tyrosinase White blotching
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Zusammenfassung:	Highlights • We investigate the causes of unexpected depigmentation induced by rhododendrol. • Melanocyte damage is related to tyrosinase activity at a certain threshold. • Melanocytes with higher tyrosinase activity produce a toxic hydroxyl-rhododendrol. • Suppression of tyrosinase activity rescues melanocytes treated with rhododendrol.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2014.07.001