Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity

Highlights • A DP-4 peptide has been identified as a functional peptide of dermatopontin. • DP-4 promoted fibrinogen fibril formation, but did not affect fibrin formation. • DP-4-induced fibrinogen fibrils enhanced adhesion of HUVECs. • The cell adhesion was mediated by syndecan, αvβ3 and β1 integri...

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Veröffentlicht in:	Journal of dermatological science 2014-10, Vol.76 (1), p.34-43
Hauptverfasser:	Wu, Weimin, Okamoto, Osamu, Kato, Aiko, Matsuo, Noritaka, Kumai, Jun, Nomizu, Motoyoshi, Fujiwara, Sakuhei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Adhesion Chondroitin Sulfate Proteoglycans - chemistry Cytoskeleton - metabolism Dermatology Dermatopontin DP-4 peptide Extracellular Matrix - metabolism Extracellular Matrix Proteins - chemistry Fibrin - chemistry Fibrinogen Fibrinogen - chemistry Fibrinogen fibril Human Umbilical Vein Endothelial Cells - cytology Humans Integrin alphaVbeta3 - metabolism Molecular Sequence Data Peptides - chemistry Protein Interaction Mapping Receptors, Vitronectin - metabolism Syndecans - metabolism Wound healing
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Zusammenfassung:	Highlights • A DP-4 peptide has been identified as a functional peptide of dermatopontin. • DP-4 promoted fibrinogen fibril formation, but did not affect fibrin formation. • DP-4-induced fibrinogen fibrils enhanced adhesion of HUVECs. • The cell adhesion was mediated by syndecan, αvβ3 and β1 integrins. • The DP-4-fibrinogen fibril might be used for a therapeutic purpose.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2014.07.002