Morning cortisol levels in schizophrenia and bipolar disorder: A meta-analysis

Highlights • We undertake the first meta-analysis of studies examining morning cortisol levels in SZ or BD, compared to controls, and to each other. • We examine potential clinical and demographic moderators of effect sizes. • Meta-analysis 2613 schizophrenia and 704 bipolar disorder cases reveal mo...

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Veröffentlicht in:	Psychoneuroendocrinology 2014-11, Vol.49, p.187-206
Hauptverfasser:	Girshkin, Leah, Matheson, Sandra L, Shepherd, Alana M, Green, Melissa J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Age Factors Behavioral psychophysiology Biological and medical sciences Biomarkers - blood Biomarkers - metabolism Bipolar Disorder - blood Bipolar Disorder - metabolism Bipolar disorders Case-Control Studies Cortisol Endocrinology & Metabolism Female Fundamental and applied biological sciences. Psychology Hormones and behavior HPA Humans Hydrocortisone - blood Hydrocortisone - metabolism Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Male Medical sciences Meta-analysis Middle Aged Miscellaneous Mood disorders Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psychoses Psychosis Psychotropic Drugs - pharmacology Schizophrenia Schizophrenia - blood Schizophrenia - metabolism Sex Characteristics Stress Time Factors Vulnerability Young Adult
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Beschreibung
Zusammenfassung:	Highlights • We undertake the first meta-analysis of studies examining morning cortisol levels in SZ or BD, compared to controls, and to each other. • We examine potential clinical and demographic moderators of effect sizes. • Meta-analysis 2613 schizophrenia and 704 bipolar disorder cases reveal moderate quality evidence of increased morning cortisol levels in both groups compared to controls. • Greater effect sizes in schizophrenia samples were revealed in established illness, cases free of medication, and inpatient. • In BD, greater morning cortisol levels were found in outpatient and non-manic participants.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2014.07.013