Prophylactic tranexamic acid in parturients at low risk for post-partum haemorrhage: systematic review and meta-analysis

Tranexamic acid is effective in reducing blood loss during various types of surgery and after trauma. No compelling evidence has yet been presented for post‐partum haemorrhage. A systematic literature search of relevant databases was performed to identify trials that assessed blood loss and transfusion incidence after tranexamic acid administration for post‐partum haemorrhage. The random effects model was used for meta‐analysis. Risk ratios (RRs) and weighted mean differences (WMDs) were calculated with 95% confidence intervals (CIs). Seven trials with a low risk of bias comparing tranexamic acid vs. placebo with a total of 1760 parturients were included in our systematic review and meta‐analysis. Blood loss was significantly lower after tranexamic acid use (WMD −140.29 ml, 95% CI −189.64 to −90.93 ml; P