A strain of Nocardia mediterranei that produces a mixture of rifamycin B and W

A strain of Nocardia mediterranei that produces a mixture of rifamycin B and W

A mutant strain, derived from Nocardia mediterranei ATCC 13685 was found to accumulate rifamycin B in shake flask as major product, but the same strain in a 500-liter fermenter, produces a mixture of rifamycin B and other ansamycin, which was identificated by C NMR as rifamycin W.

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Veröffentlicht in:Biotechnology letters 1990, Vol.12 (4), p.283-288
Hauptverfasser: ALVAREZ, A. M, GELISTA, A, RESENDIZ, B, RODRIGUEZ, F. N
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Production of active biomolecules
rifamycin
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Zusammenfassung:A mutant strain, derived from Nocardia mediterranei ATCC 13685 was found to accumulate rifamycin B in shake flask as major product, but the same strain in a 500-liter fermenter, produces a mixture of rifamycin B and other ansamycin, which was identificated by C NMR as rifamycin W.
ISSN:0141-5492
1573-6776