Double-stranded DNA fragment shows a significant decrease in double-helix stability after binding of monofunctional platinum amine compounds

The antitumor drug cis-diamminedichloroplatinum (II) (cDDP) preferentially binds to two neighboring guanine bases of DNA. It has been suggested that this chelation induces a serious distortion of the DNA, resulting in a denaturation up to several base pairs. Recently, NMR studies and molecular mecha...

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Veröffentlicht in:	Journal of the American Chemical Society 1989-05, Vol.111 (11), p.4123-4125
Hauptverfasser:	Van Garderen, Carla J, Van Houte, Leo P. A, Van den Elst, Hans, Van Boom, Jacques H, Reedijk, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Molecular biophysics
Online-Zugang:	Volltext
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Zusammenfassung:	The antitumor drug cis-diamminedichloroplatinum (II) (cDDP) preferentially binds to two neighboring guanine bases of DNA. It has been suggested that this chelation induces a serious distortion of the DNA, resulting in a denaturation up to several base pairs. Recently, NMR studies and molecular mechanics of oligonucleotides containing eight or more base pairs showed that the distortion is small; all base pairs, even those of the platinated guanines, are observed.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja00193a067