Here come the newcomer granules, better late than never

Highlights • Different Munc18/SNARE complexes mediate distinct insulin exocytotic events in β-cells. • The Syntaxin-3/VAMP8/SNAP25 SNARE complex mediates newcomer granule fusion. • Newcomer granules have a short or no residence time at the PM before fusion. • Newcomer granules are larger contributor...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2014-08, Vol.25 (8), p.381-388
1. Verfasser:	Gaisano, Herbert Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Endocrinology & Metabolism Exocytosis - physiology Humans Insulin - metabolism insulin secretion Insulin-Secreting Cells - metabolism newcomer granules SNARE proteins SNARE Proteins - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Different Munc18/SNARE complexes mediate distinct insulin exocytotic events in β-cells. • The Syntaxin-3/VAMP8/SNAP25 SNARE complex mediates newcomer granule fusion. • Newcomer granules have a short or no residence time at the PM before fusion. • Newcomer granules are larger contributors to insulin secretion than predocked granules.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2014.03.005