Capture and Release of Cancer Cells Based on Sacrificeable Transparent MnO2 Nanospheres Thin Film

A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of CTCs is reported. The enhanced local topography interaction between extracellular matrix scaffolds and the antibody‐coated substrate leads to improved capture efficiency. CTCs captured from artificial bloo...

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Veröffentlicht in:	Advanced healthcare materials 2014-09, Vol.3 (9), p.1420-1425
Hauptverfasser:	Huang, Qinqin, Chen, Bolei, He, Rongxiang, He, Zhaobo, Cai, Bo, Xu, Junhua, Qian, Weiyi, Chan, Helen Laiwa, Liu, Wei, Guo, Shishang, Zhao, Xing-Zhong, Yuan, Jikang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies - metabolism Antigens, Neoplasm - metabolism Biological and medical sciences Cell Adhesion Molecules - metabolism Cell Line, Tumor cell release Cell Separation - instrumentation Cell Survival circulating tumor cells Epithelial Cell Adhesion Molecule Humans Manganese Compounds - chemistry Medical sciences MnO2 nanospheres Nanospheres - chemistry Nanospheres - ultrastructure Nanostructures Neoplastic Cells, Circulating - chemistry Neoplastic Cells, Circulating - metabolism Oxalic Acid Oxides - chemistry Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments transparent
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Zusammenfassung:	A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of CTCs is reported. The enhanced local topography interaction between extracellular matrix scaffolds and the antibody‐coated substrate leads to improved capture efficiency. CTCs captured from artificial blood sample can be cultured and released, represent a new functional material capable of CTCs isolation and culture for subsequent studies.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201300670