Clinical commentary: Medical ethics and the ramifications of equipoise in clinical research. Is a confirmatory trial using a non-bevacizumab containing arm feasible in patients with recurrent cervical cancer?

Highlights • This clinical commentary addresses the topic of medical ethics in clinical research. • Describes the ethical principle of ‘clinical equipoise’ as it relates to clinical trials in gynecologic oncology • Can clinical equipoise exist in harmony with medical ethics and promote progress in c...

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Veröffentlicht in:	Gynecologic oncology 2014-09, Vol.134 (3), p.447-449
Hauptverfasser:	Krill, Lauren S, Adelson, Joel W, Randall, Leslie M, Bristow, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Bevacizumab Bioethical Issues Biomedical Research - ethics Clinical Trials as Topic - ethics Ethics, Medical Female Hematology, Oncology and Palliative Medicine Humans Neoplasm Recurrence, Local - drug therapy Obstetrics and Gynecology Testosterone - analogs & derivatives Testosterone - therapeutic use Uterine Cervical Neoplasms - drug therapy
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Beschreibung
Zusammenfassung:	Highlights • This clinical commentary addresses the topic of medical ethics in clinical research. • Describes the ethical principle of ‘clinical equipoise’ as it relates to clinical trials in gynecologic oncology • Can clinical equipoise exist in harmony with medical ethics and promote progress in cancer research simultaneously?
ISSN:	0090-8258 1095-6859
DOI:	10.1016/j.ygyno.2014.06.017