Predictors of pharmacological treatment outcomes with atomoxetine or methylphenidate in patients with attention-deficit/hyperactivity disorder from China, Egypt, Lebanon, Russian Federation, Taiwan, and United Arab Emirates

Summary Background The reduced availability of data from non‐Western countries limits our ability to understand attention‐deficit/hyperactivity disorder (ADHD) treatment outcomes, specifically, adherence and persistence of ADHD in children and adolescents. This analysis assessed predictors of treatment outcomes in a non‐Western cohort of patients with ADHD treated with atomoxetine or methylphenidate. Methods Data from a 12‐month, prospective, observational study in outpatients aged 6–17 years treated with atomoxetine (N = 234) or methylphenidate (N = 221) were analysed post hoc to determine potential predictors of treatment outcomes. Participating countries included the Russian Federation, China, Taiwan, Egypt, United Arab Emirates and Lebanon. Factors associated with remission were analysed with stepwise multiple logistic regression and classification and regression trees (CART). Cox proportional hazards models with propensity score adjustment assessed differences in atomoxetine persistence among initial‐dose cohorts. Results In patients treated with atomoxetine who had available dosing information (N = 134), Cox proportional hazards revealed lower (