Epigenetics in immune development and in allergic and autoimmune diseases

Highlights • Epigenetic mechanisms are critical for normal immune development. • Epigenetic mechanisms provide a mechanistic framework for understanding how the environment affects genes. • Disruption in epigenetic pathways has been associated with immune diseases. • In this review we cover the epig...

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Veröffentlicht in:	Journal of reproductive immunology 2014-10, Vol.104, p.43-48
Hauptverfasser:	Martino, David, Kesper, Dörthe A, Amarasekera, Manori, Harb, Hani, Renz, Harald, Prescott, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology DNA methylation Epigenesis, Genetic - immunology Epigenetics Genome, Human - immunology Humans Hypersensitivity - genetics Hypersensitivity - immunology Immune development Immune disease Immune function Obstetrics and Gynecology
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Zusammenfassung:	Highlights • Epigenetic mechanisms are critical for normal immune development. • Epigenetic mechanisms provide a mechanistic framework for understanding how the environment affects genes. • Disruption in epigenetic pathways has been associated with immune diseases. • In this review we cover the epigenetic aspects of immune development and disease.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2014.05.003