Csp3–Csp3 Homocoupling Reaction of Benzyl Halides Catalyzed by Rhodium

Csp3–Csp3 Homocoupling Reaction of Benzyl Halides Catalyzed by Rhodium

A highly reactive alkylrhodium complex was formed from Me2Zn and RhCl(PPh3)3 and effectively catalyzed a Csp3–Csp3 homocoupling reaction of benzyl halides. A Csp3–Csp3 coupling reaction using Rh catalyst has not been reported up to now. The reaction proceeded under very mild conditions and gave the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2014-07, Vol.16 (14), p.3756-3759
Hauptverfasser: Sato, Kazuyuki, Inoue, Yuichi, Mori, Tomohisa, Sakaue, Atsushi, Tarui, Atsushi, Omote, Masaaki, Kumadaki, Itsumaro, Ando, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Benzyl Compounds - chemistry
Catalysis
Combinatorial Chemistry Techniques
Hydrocarbons, Halogenated - chemistry
Molecular Structure
Rhodium - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A highly reactive alkylrhodium complex was formed from Me2Zn and RhCl(PPh3)3 and effectively catalyzed a Csp3–Csp3 homocoupling reaction of benzyl halides. A Csp3–Csp3 coupling reaction using Rh catalyst has not been reported up to now. The reaction proceeded under very mild conditions and gave the corresponding homocoupling products even if they had reactive substituents such as an uncovered formyl or hydroxymethyl group.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501619w