Thiazides and the risk of hypokalemia in the general population

OBJECTIVES:Hypokalemia is a frequent adverse reaction to thiazide diuretics, but is often asymptomatic. However, even asymptomatic hypokalemia may contribute to chronic disabilities and mortality. The aim of this study was to assess the risk of thiazide-induced hypokalemia in men and women in the ge...

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Veröffentlicht in:	Journal of hypertension 2014-10, Vol.32 (10), p.2092-2097
Hauptverfasser:	Rodenburg, Eline M, Visser, Loes E, Hoorn, Ewout J, Ruiter, Rikje, Lous, Jan J, Hofman, Albert, Uitterlinden, André G, Stricker, Bruno H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin Receptor Antagonists Cohort Studies Female Humans Hypokalemia - chemically induced Hypokalemia - epidemiology Male Middle Aged Netherlands - epidemiology Potassium - blood Renin-Angiotensin System - drug effects Risk Sodium Chloride Symporter Inhibitors - adverse effects Thiazides - adverse effects
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Zusammenfassung:	OBJECTIVES:Hypokalemia is a frequent adverse reaction to thiazide diuretics, but is often asymptomatic. However, even asymptomatic hypokalemia may contribute to chronic disabilities and mortality. The aim of this study was to assess the risk of thiazide-induced hypokalemia in men and women in the general population. METHODS:Within the Rotterdam study, which is a population-based cohort study, the association between thiazide exposure and hypokalemia (serum potassium level
ISSN:	0263-6352 1473-5598
DOI:	10.1097/HJH.0000000000000299