Cirrhosis but not neutropenia is associated with the development of infection in patients with chronic hepatitis C undergoing treatment with pegylated interferon-alpha and ribavirin

Summary Peginterferon‐alpha (PegIFNa) frequently causes neutropenia, mainly due to bone marrow suppression. The aim of this study was to explore factors that are associated with infections during antiviral treatment. We analysed data from 275 chronic hepatitis C (CHC) patients with compensated liver...

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Veröffentlicht in:	Journal of viral hepatitis 2014-09, Vol.21 (9), p.624-632
Hauptverfasser:	Striki, A., Manolakopoulos, S., Deutsch, M., Mela, M., Kalafateli, M., Schini, M., Anagnostou, O., Triantos, C., Andreadis, I., Ketikoglou, I., Papatheodoridis, G., Pectasides, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Bacterial Infections - epidemiology chronic hepatitis C cirrhosis Female Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Humans infection's hazard Interferon-alpha - adverse effects Interferon-alpha - therapeutic use leucopenia Liver Cirrhosis - complications Male Middle Aged neutropenia Neutropenia - chemically induced Neutropenia - complications pegylated interferon-a Retrospective Studies Ribavirin - adverse effects Ribavirin - therapeutic use Young Adult
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Zusammenfassung:	Summary Peginterferon‐alpha (PegIFNa) frequently causes neutropenia, mainly due to bone marrow suppression. The aim of this study was to explore factors that are associated with infections during antiviral treatment. We analysed data from 275 chronic hepatitis C (CHC) patients with compensated liver disease who underwent 318 courses of PegIFNa and ribavirin. Neutropenia was defined as neutrophils
ISSN:	1352-0504 1365-2893
DOI:	10.1111/jvh.12197