Evaluation of efficacy, biodistribution and safety of antibiotic-free plasmid encoding somatostatin genes delivered by attenuated Salmonella enterica serovar Choleraesuis

Evaluation of efficacy, biodistribution and safety of antibiotic-free plasmid encoding somatostatin genes delivered by attenuated Salmonella enterica serovar Choleraesuis

Highlights • Asd-based balanced-lethal system for DNA vaccine was evaluated in this paper. • The C501(pVGS/2SS-asd) vaccine could induce systemic and mucosal immune responses. • The C501 (pVGS/2SS-asd) vaccine is safe and stable for clinical use in large animals. • The risk of gene integration into...

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Veröffentlicht in:Vaccine 2014-03, Vol.32 (12), p.1368-1374
Hauptverfasser: Liang, Aixin, Riaz, Hasan, Dong, Fangxiao, Luo, Xuan, Yu, Xue, Han, Yanguo, Chong, Zhenlu, Han, Li, Guo, Aizhen, Yang, Liguo
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Allergy and Immunology
Animals
Applied microbiology
Aspartate-Semialdehyde Dehydrogenase - genetics
Bacteriology
Biological and medical sciences
DNA vaccine
Female
Fundamental and applied biological sciences. Psychology
Genes, Reporter
Immunity, Humoral
Immunoglobulin G - blood
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Plasmids - genetics
Plasmids - immunology
Plasmids - pharmacokinetics
Safety
Salmonella
Salmonella enterica
Salmonella enterica - genetics
Salmonella enterica - immunology
Somatostatin
Somatostatin - genetics
Somatostatin - immunology
Tissue Distribution
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - genetics
Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:Highlights • Asd-based balanced-lethal system for DNA vaccine was evaluated in this paper. • The C501(pVGS/2SS-asd) vaccine could induce systemic and mucosal immune responses. • The C501 (pVGS/2SS-asd) vaccine is safe and stable for clinical use in large animals. • The risk of gene integration into the host cellular genome was negligible.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.01.026