The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

The factors influencing virological response to first‐line combined antiretroviral therapy (cART) in an Italian cohort of HIV‐1‐infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first‐line cART between 2001 and 2011 and who had at least one follow‐up of HIV‐1 RNA. The primary endpoint was virological success, defined as the first viral load