Effects of Different Antigenic Stimuli on Thymic Function and Interleukin-7/CD127 System in Patients with Chronic HIV Infection

BACKGROUND:We tested if an increase in immune activation and a decrease in CD4 T cells induced by different antigenic stimuli could be associated with changes in the thymic function and the interleukin (IL)-7/CD127 system. METHODS:Twenty-six HIV-infected patients under combined antiretroviral therap...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2014-08, Vol.66 (5), p.466-472
Hauptverfasser: Castro, Pedro, Torres, Berta, López, Anna, González, Raquel, Vilella, Anna, Nicolas, Jose M, Gallart, Teresa, Pumarola, Tomàs, Sánchez, Marcelo, Leal, Manuel, Vallejo, Alejandro, Bayas, José M, Gatell, José M, Plana, Montserrat, García, Felipe
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Sprache:eng
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Zusammenfassung:BACKGROUND:We tested if an increase in immune activation and a decrease in CD4 T cells induced by different antigenic stimuli could be associated with changes in the thymic function and the interleukin (IL)-7/CD127 system. METHODS:Twenty-six HIV-infected patients under combined antiretroviral therapy (cART) were randomized to receive, during 12 months, a complete immunization schedule (7 vaccines and 15 doses) or placebo. Thereafter, cART was interrupted during 6 months. Changes in the thymic function and the IL-7/CD127 system after 3 different antigenic stimuli (vaccines, episodes of low-level intermittent viremia before cART interruption, or viral load rebound after cART interruption) were assessed. RESULTS:During the period on cART, neither vaccines nor low-level viremia influenced thymic function or IL-7/CD127 system parameters. By analyzing the cohort as a whole while on cART, a significant improvement was observed in the thymic function as measured by an increase in the thymic volume (P = 0.024), T-cell receptor excision circle–bearing cells (P = 0.012), and naive CD4 and CD8 T cells (P = 0.069 both). No significant changes were observed in the IL-7/CD127 system. After cART interruption, a decrease in T-cell receptor excision circles (P < 0.001) and naive CD8 T cells (P < 0.001), an increase in IL-7 and expression of CD127 on naive and memory CD4 T cells (P = 0.028, P = 0.088, and P = 0.04, respectively), and a significant decrease in CD127 on naive and memory CD8 T cells (P = 0.01, P = 0.006, respectively) were observed. CONCLUSIONS:Low-level transient antigenic stimuli during cART were not associated with changes in the thymic function or the IL-7/CD127 system. Conversely, viral load rebound very early after cART interruption influenced the thymic function and the IL-7/CD127 system. Clinical Trials.gov number NCT00329251.
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000000207