Assembling the Protein Architecture of the Budding Yeast Kinetochore-Microtubule Attachment using FRET

The kinetochore is a multiprotein machine that couples chromosome movement to microtubule (MT) polymerization and depolymerization. It uses numerous copies of at least three MT-binding proteins to generate bidirectional movement. The nanoscale organization of these proteins within the kinetochore pl...

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Veröffentlicht in:	Current biology 2014-07, Vol.24 (13), p.1437-1446
Hauptverfasser:	Aravamudhan, Pavithra, Felzer-Kim, Isabella, Gurunathan, Kaushik, Joglekar, Ajit P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Fluorescence Resonance Energy Transfer Kinetochores - metabolism Microtubule-Associated Proteins - metabolism Microtubules - metabolism Models, Biological Multiprotein Complexes - metabolism Nuclear Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - metabolism Saccharomycetales - metabolism
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