BacMam virus-based surface display of the infectious bronchitis virus (IBV) S1 glycoprotein confers strong protection against virulent IBV challenge in chickens

Highlights • BV-Dual-S1 was generated based on BacMam virus and baculovirus display technology. • BV-Dual-S1 showed enhanced immunogenicity and protection in chickens. • Cytotoxic T lymphocyte responses were critical in controlling IBV in poultry. • BV-Dual-S1 offers an equally efficient but safer p...

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Veröffentlicht in:	Vaccine 2014-02, Vol.32 (6), p.664-670
Hauptverfasser:	Zhang, Jie, Chen, Xiao-Wei, Tong, Tie-Zhu, Ye, Yu, Liao, Ming, Fan, Hui-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology Avian infectious bronchitis virus BacMam virus Baculoviridae Baculovirus Baculovirus display technology Biological and medical sciences Chickens Chickens - immunology Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - veterinary Fundamental and applied biological sciences. Psychology IBV-M41 Immune system Immunity, Cellular Immunization Infectious bronchitis virus Infectious bronchitis virus - immunology Infectious diseases Lymphocytes Mammals Medical research Microbiology Miscellaneous Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Poultry Diseases - virology S1 protein Spike Glycoprotein, Coronavirus - immunology T-Lymphocytes - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology Viral Vaccines - immunology Virology
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Beschreibung
Zusammenfassung:	Highlights • BV-Dual-S1 was generated based on BacMam virus and baculovirus display technology. • BV-Dual-S1 showed enhanced immunogenicity and protection in chickens. • Cytotoxic T lymphocyte responses were critical in controlling IBV in poultry. • BV-Dual-S1 offers an equally efficient but safer prophylaxis against IBV infection. • Recombinant BacMam viruses serve as a powerful tool in avian vaccine developments.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.12.006