Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1

Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid-resistant Enterococcus faecalis isolated in the clinic is lacking. In this study, we report the ent...

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Veröffentlicht in:	Archives of microbiology 2014-07, Vol.196 (7), p.513-516
Hauptverfasser:	Yu, Zhijian, Chen, Zhong, Cheng, Hang, Zheng, Jinxin, Li, Duoyun, Deng, Xiangbin, Pan, Weiguang, Yang, Weizhi, Deng, Qiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Annotations Anti-Bacterial Agents - pharmacology Antibiotics Biochemistry Biomedical and Life Sciences Biotechnology Cell Biology Comparative analysis Drug resistance Drug Resistance, Bacterial - genetics Ecology Enterococcus faecalis Enterococcus faecalis - classification Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Genes genetic variation genome Genome, Bacterial - genetics Genomes Genomics Life Sciences Linezolid Microbial Ecology Microbiology Mutation nucleotide sequences Original Paper Oxazolidinones - pharmacology Phylogenetics Phylogeny Proteins resistance mechanisms sequence analysis Species Specificity Staphylococcus infections Streptococcus infections Transfer RNA Virulence Virulence Factors - genetics
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Zusammenfassung:	Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid-resistant Enterococcus faecalis isolated in the clinic is lacking. In this study, we report the entire genome sequence, genomic characteristics and virulence factors of a pathogenic E. faecalis strain, DENG1. Our results showed considerable differences in genomic characteristics and virulence factors compared with other E. faecalis strains (V583 and OG1RF). The genome of this LZD-resistant E. faecalis strain can be used as a reference to study the mechanism of LZD resistance and the phylogenetic relationship of E. faecalis strains worldwide.
ISSN:	0302-8933 1432-072X
DOI:	10.1007/s00203-014-0986-y