Changes in gene expression profile in two multidrug resistant cell lines derived from a same drug sensitive cell line

Highlights • K562-derived MDR cell lines shared changes in some biological functions. • The number of differentially expressed genes was different for each derived cell line. • In both K562-derived MDR cell lines ABCB1 was overexpressed in respect to K562. • In both K562-derived MDR cell lines the A...

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Veröffentlicht in:	Leukemia research 2014-08, Vol.38 (8), p.983-987
Hauptverfasser:	Moreira, Miguel Angelo Martins, Bagni, Carolina, de Pinho, Marcos Barcelos, Mac-Cormick, Thaís Messias, dos Santos Mota, Mateus, Pinto-Silva, Flávio Eduardo, Daflon-Yunes, Nathalia, Rumjanek, Vivian Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCB transporters ABCB1 ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cancer Cell Line, Tumor DNA Methylation Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Leukemic Hematology, Oncology and Palliative Medicine Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology MDR cell lines Methylation Microarray Analysis Multidrug resistance Promoter Regions, Genetic Transcriptome - drug effects
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Zusammenfassung:	Highlights • K562-derived MDR cell lines shared changes in some biological functions. • The number of differentially expressed genes was different for each derived cell line. • In both K562-derived MDR cell lines ABCB1 was overexpressed in respect to K562. • In both K562-derived MDR cell lines the ABCB1 promoter was totally demethylated. • Our findings showed that NOTCH pathway was affected in both K562-derived MDR cells.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2014.06.001