Epigenetic silencing of BTB and CNC homology 2 and concerted promoter CpG methylation in gastric cancer

Highlights • We found a Not I site methylated on BACH2 promoter in gastric tumors. • The methylation was significantly associated with decreased gene expression. • Knockdown of BACH2 by shRNA increased cell proliferation in gastric cancer cells. • BACH2 promoter methylation paralleled that of previo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-09, Vol.351 (2), p.206-214
Hauptverfasser:	Haam, Keeok, Kim, Hee-Jin, Lee, Kyung-Tae, Kim, Jeong-Hwan, Kim, Mirang, Kim, Seon-Young, Noh, Seung-Moo, Song, Kyu-Sang, Kim, Yong Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	BACH2 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Cell growth Cell Growth Processes - genetics Cell Line, Tumor Concerted methylation CpG Islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Epigenetics Female Gastric cancer Gene expression Gene Knockdown Techniques Gene Silencing Genetic testing Hematology, Oncology and Palliative Medicine Hospitals Humans Male Middle Aged Patients Promoter Regions, Genetic RLGS Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We found a Not I site methylated on BACH2 promoter in gastric tumors. • The methylation was significantly associated with decreased gene expression. • Knockdown of BACH2 by shRNA increased cell proliferation in gastric cancer cells. • BACH2 promoter methylation paralleled that of previously identified targets. • We propose that methylated loci may be targets for therapeutic treatment.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.05.009