Molecular mechanisms of probiotic action: a proteomic perspective

Molecular mechanisms of probiotic action: a proteomic perspective

Graphical abstract Highlights ► Proteomics contributed to clarify mechanisms of adaptation to GIT environment. ► Proteomic and in vitro tests led to identify proteins involved in host-adhesion. ► Moonlighting proteins (ENO, GAPDH, EF-Tu, etc.) act as adhesion promoting factors. ► Several extracellul...

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Veröffentlicht in:Current opinion in microbiology 2012-06, Vol.15 (3), p.390-396
Hauptverfasser: Siciliano, Rosa Anna, Mazzeo, Maria Fiorella
Format: Artikel
Sprache:eng
Schlagworte:
bacterial adhesion
Bacterial Physiological Phenomena
digestion
Gastrointestinal Tract - microbiology
human health
Humans
immune response
immunomodulators
intestinal mucosa
nutrients
pathogens
Pathology
Probiotics
proteomics
Proteomics - methods
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Zusammenfassung:Graphical abstract Highlights ► Proteomics contributed to clarify mechanisms of adaptation to GIT environment. ► Proteomic and in vitro tests led to identify proteins involved in host-adhesion. ► Moonlighting proteins (ENO, GAPDH, EF-Tu, etc.) act as adhesion promoting factors. ► Several extracellular proteins have also immunomodulatory properties. ► Proteomics may have a role in selecting new strains with predictable functionality.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2012.03.006