Prenatal terbutaline exposure in the rat: Selective effects on development of noradrenergic projections to cerebellum

Terbutaline, used in the treatment of premature labor and asthma, crosses the placenta and can stimulate β 2-adrenergic receptors in the fetus. This study examines the effects of prenatal exposure to terbutaline (10 mg/kg SC on gestational days 17, 18 and 19) on the development of noradrenergic proj...

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Veröffentlicht in:Brain research bulletin 1989-10, Vol.23 (4), p.263-265
Hauptverfasser: Slotkin, T.A., Baker, F.E., Dobbins, S.S., Eylers, J.P., Lappi, S.E., Seidler, F.J.
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Sprache:eng
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Zusammenfassung:Terbutaline, used in the treatment of premature labor and asthma, crosses the placenta and can stimulate β 2-adrenergic receptors in the fetus. This study examines the effects of prenatal exposure to terbutaline (10 mg/kg SC on gestational days 17, 18 and 19) on the development of noradrenergic projections in brain regions of the fetal and neonatal rat, using synaptosomal uptake of [ 3H]norepinephrine as a marker for synaptogenesis. Although terbutaline exposure did not compromise body or brain region growth, uptake was adversely affected selectively in the cerebellum, a region which also displays close coupling of fetal β 2-receptors to control of cell development near term. These results thus provide biochemical evidence that terbutaline may be a neurobehavioral teratogen.
ISSN:0361-9230
1873-2747
DOI:10.1016/0361-9230(89)90206-2