Glycosylated Hemoglobin and Coronary Artery Disease in Patients Without Diabetes Mellitus

Background Abnormal glucose metabolism is a major determinant of coronary artery disease (CAD) and mortality in developed countries. Glycosylated hemoglobin (HbA1c) is a more stable, accurate parameter of glucose homeostasis than fasting glycemia, thus providing prognostic information in diabetics. However, its role and relationship with CAD remains unclear in non-diabetics. Purpose To evaluate the relationship between HbA1c and CAD in a consecutive cohort of patients without diabetes mellitus. Methods Non-diabetic patients undergoing coronary angiography between April 2007 and October 2012 were included. Additionally carotid intima−media thickness (C-IMT) was evaluated during hospitalization in a consecutive cohort of patients. Results 1,703 consecutive patients were included and divided according to HbA1c tertiles (