RNA switch at enhancers

RNA switch at enhancers

Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epige...

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Veröffentlicht in:Nature genetics 2014-09, Vol.46 (9), p.929-931
Hauptverfasser: Quinn, Jeffrey J, Chang, Howard Y
Format: Artikel
Sprache:eng
Schlagworte:
631/136/2086
631/208/177
631/337/176
Agriculture
Animal Genetics and Genomics
Animals
Bioengineering
Biomedicine
Cancer Research
Chromosomal Proteins, Non-Histone - genetics
Cytogenetics
Deoxyribonucleic acid
DNA
Drosophila Proteins - genetics
Epigenetic inheritance
Gene expression
Gene Function
Gene loci
Genes
Genes, Switch
Genetic research
Human Genetics
Mammals
Muscles
news-and-views
Polycomb-Group Proteins - genetics
Properties
Proteins
Response Elements
RNA
RNA, Untranslated
Silence
Transcription factors
Transcription, Genetic
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Beschreibung
Zusammenfassung:Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
ISSN:1061-4036
1546-1718
DOI:10.1038/ng.3074