Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.

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Veröffentlicht in:Organic & biomolecular chemistry 2014-10, Vol.12 (37), p.7197-7200
Hauptverfasser: Bertucci, Michael A, Lee, Stephen J, Gagné, Michel R
Format: Artikel
Sprache:eng
Schlagworte:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemistry
Hydrazines - chemical synthesis
Hydrazines - chemistry
Molecular Structure
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Zusammenfassung:A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01156b