Variation of mouse oocyte sensitivity to griseofulvin-induced aneuploidy during the second meiotic division

The effects of griseofulvin (GF) treatment during the second meiotic division of oogenesis were investigated by cytogenetic analysis of mouse one-cell (1-CI) zygotes. After determining the duration of fertilization and the second meiotic division, 1500 mg/kg GF were administered to superovulated mic...

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Veröffentlicht in:	Mutagenesis 1995-03, Vol.10 (2), p.113-121
Hauptverfasser:	Marchetti, Francesco, Mailhes, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Biological and medical sciences Cell Division - drug effects Cytogenetics Female Fertilization Fundamental and applied biological sciences. Psychology Griseofulvin - pharmacology Male Meiosis - drug effects Meiosis - physiology Mice Mice, Inbred ICR Molecular and cellular biology Molecular genetics Mutagenesis. Repair Oocytes - drug effects Oocytes - physiology Oogenesis - drug effects Oogenesis - physiology Time Factors Zygote - drug effects
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Zusammenfassung:	The effects of griseofulvin (GF) treatment during the second meiotic division of oogenesis were investigated by cytogenetic analysis of mouse one-cell (1-CI) zygotes. After determining the duration of fertilization and the second meiotic division, 1500 mg/kg GF were administered to superovulated mice at 10, 12 or 14 h after human chorionic gonadotrophin (HCG) injection. The results showed that GF reduced the frequencies of fertilized oocytes (P
ISSN:	0267-8357 1464-3804
DOI:	10.1093/mutage/10.2.113