Phorbaketals L–N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Three new sesterterpenoids, phorbaketals L–N (1–3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4μM)...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-09, Vol.24 (17), p.4095-4098
Hauptverfasser:	Lee, Yehee, Wang, Weihong, Kim, Hiyoung, Giri, Awadut G., Won, Dong Hwan, Hahn, Dongyup, Baek, Kyung Ryul, Lee, Jihye, Yang, Inho, Choi, Hyukjae, Nam, Sang-Jip, Kang, Heonjoong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation - drug effects Cytotoxicity Dose-Response Relationship, Drug Humans Molecular Structure Pancreatic Neoplasms - pathology Phorbaketals Phorbas sp Porifera - chemistry Sesterterpenes - chemistry Sesterterpenes - isolation & purification Sesterterpenes - toxicity Structure-Activity Relationship
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Zusammenfassung:	Three new sesterterpenoids, phorbaketals L–N (1–3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4μM).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.07.066