Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma

KLK6 is a secreted trypsin-like serine protease. mRNA expression and its association with colon cancer (CC) progression was studied using quantitative real-time PCR. We examined the expression of in 232 colon tissues (cancerous, non-cancerous, and adenomatous). We proved that expression in CC behave...

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Veröffentlicht in:	Biological chemistry 2014-09, Vol.395 (9), p.1105-1117
Hauptverfasser:	Vakrakou, Athina, Devetzi, Marina, Papachristopoulou, Georgia, Malachias, Apostolos, Scorilas, Andreas, Xynopoulos, Dimitris, Talieri, Maroulio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adult Aged Aged, 80 and over Cell Line, Tumor cell lines colon adenomas colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Disease Progression Disease-Free Survival Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Intestinal Mucosa - pathology kallikrein-related peptidase 6 Kallikreins - genetics Kallikreins - metabolism Kaplan-Meier Estimate Middle Aged ROC Curve tumor markers
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Zusammenfassung:	KLK6 is a secreted trypsin-like serine protease. mRNA expression and its association with colon cancer (CC) progression was studied using quantitative real-time PCR. We examined the expression of in 232 colon tissues (cancerous, non-cancerous, and adenomatous). We proved that expression in CC behaves as a continuous variable, as its expression correlates significantly with increasing tumor stage ( =0.004) and histological grade ( =0.007). Interestingly, the expression of in adenomas was significantly higher than that in the cancerous or non-cancerous tissues examined (
ISSN:	1431-6730 1437-4315
DOI:	10.1515/hsz-2014-0166