Engineering pathways for transformations of morphine alkaloids

Semisynthetic opiates provide some of the most potent analgesic compounds currently in clinical use, the majority of which are synthesized from the naturally occurring alkaloids morphine, codeine and thebaine. The use of recombinant DNA technology to engineer pathways for the biological synthesis of...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 1995, Vol.13 (6), p.200-205
Hauptverfasser:	Bruce, Neil C., French, Christopher E., Hailes, Anne M., Long, Marianne T., Rathbone, Deborah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacteria Biological and medical sciences Biotechnology chemical reactions Fundamental and applied biological sciences. Psychology genetic engineering Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology opium alkaloids recombinant DNA
Online-Zugang:	Volltext
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Zusammenfassung:	Semisynthetic opiates provide some of the most potent analgesic compounds currently in clinical use, the majority of which are synthesized from the naturally occurring alkaloids morphine, codeine and thebaine. The use of recombinant DNA technology to engineer pathways for the biological synthesis of semisynthetic opiate drugs could offer significant advantages over existing chemical methods and may, ultimately, provide novel biosynthetic routes for the development of new therapeutics.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/S0167-7799(00)88946-5