Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer

Highlights • We have identified CLDN1 as a novel target of miR-375 in non-small cell lung cancer. • Overexpression of miR-375 down-regulates and knockdown of miR-375 up-regulates CLDN1 mRNA and protein, respectively. • Overexpression of miR-375 promotes cell migration. • High expression of miR-375 i...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-09, Vol.85 (3), p.366-372
Hauptverfasser:	Yoda, Satoshi, Soejima, Kenzo, Hamamoto, Junko, Yasuda, Hiroyuki, Nakayama, Sohei, Satomi, Ryosuke, Terai, Hideki, Ikemura, Shinnosuke, Sato, Takashi, Naoki, Katsuhiko, Betsuyaku, Tomoko
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adult Aged Aged, 80 and over Base Sequence Binding Sites Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Cell Line, Tumor Claudin-1 Claudin-1 - genetics Female Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences MicroRNAs - chemistry MicroRNAs - genetics Middle Aged Migration miR-375 Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Neoplasm Staging Non-small-cell lung cancer Pneumology Prognosis Pulmonary/Respiratory Receptor, Epidermal Growth Factor - genetics RNA Interference RNA, Messenger - chemistry RNA, Messenger - genetics Survival Target Tumors Tumors of the respiratory system and mediastinum
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Beschreibung
Zusammenfassung:	Highlights • We have identified CLDN1 as a novel target of miR-375 in non-small cell lung cancer. • Overexpression of miR-375 down-regulates and knockdown of miR-375 up-regulates CLDN1 mRNA and protein, respectively. • Overexpression of miR-375 promotes cell migration. • High expression of miR-375 is associated with poor survival in non-small cell lung cancer.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2014.06.009