A Case of Fatal Lomotil® Overdosage

A 3 1/2-year-old British girl died in cardio-pulmonary arrest after ingesting an unknown amount of Lomotil® tablets. Chemical analysis by gas-liquid chromatography confirmed the presence of high levels of diphenoxylate in the blood as well as stomach and intestinal contents. No diphenoxylate was fou...

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Veröffentlicht in:	Medicine, science, and the law science, and the law, 1982-07, Vol.22 (3), p.210-214
Hauptverfasser:	Ragheb, Sameeh Abu AL, Dajani, Basem M., Salhab, Abdul Azeem, Amr, Sameer S., Shaker, Kandeel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atropine - poisoning Brain Diseases - chemically induced Brain Diseases - pathology Child, Preschool Chromatography, Gas Chromatography, Thin Layer Diphenoxylate - analysis Diphenoxylate - poisoning Drug Combinations - poisoning Female Heart Arrest - chemically induced Heart Arrest - mortality Humans Isonipecotic Acids - poisoning
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Beschreibung
Zusammenfassung:	A 3 1/2-year-old British girl died in cardio-pulmonary arrest after ingesting an unknown amount of Lomotil® tablets. Chemical analysis by gas-liquid chromatography confirmed the presence of high levels of diphenoxylate in the blood as well as stomach and intestinal contents. No diphenoxylate was found in the urine. At autopsy the intestines were congested, but the main pathology was in the cerebellum, which showed typical changes described by others as ‘respirator brain’. The deceased was not put on a respirator and did not receive naloxone.
ISSN:	0025-8024 2042-1818
DOI:	10.1177/002580248202200310