The subchronic toxicity and teratogenicity of alternariol monomethyl ether produced by alternaria solani

The subchronic toxicity and teratogenicity of alternariol monomethyl ether produced by alternaria solani

Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was ma...

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Veröffentlicht in:Food and chemical toxicology 1982-01, Vol.20 (6), p.899-902
Hauptverfasser: pollock, G.A., disabatino, C.E., heimsch, R.C., Hilblink, D.R.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Drug-Induced - etiology
Alternaria - metabolism
Alternaria solani
Animals
Cricetinae
Dose-Response Relationship, Drug
Female
food contamination
horticultural crops
Lactones - toxicity
Male
Mesocricetus
Mitosporic Fungi - metabolism
Mycotoxins - toxicity
Pregnancy
Rats
Rats, Inbred Strains
Species Specificity
Teratogens
Time Factors
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Beschreibung
Zusammenfassung:Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was maternally toxic and foetotoxic to Syrian golden hamsters when given ip at 200 mg/kg body weight on day 8 of gestation. No such effects were observed at dose levels of 50 or 100 mg/kg.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0015-6264(82)80225-3