AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles

AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles

A unique method for AgNO2-mediated direct nitration of the quinoxaline tertiary C-H bond and direct conversion of 2-methyl quinoxalines into 2-quinoxaline nitriles under oxidative conditions has been developed. This protocol provides an efficient way to access quinoxaline containing nitroalkanes and...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-09, Vol.50 (74), p.10857-10860
Hauptverfasser: Wu, Degui, Zhang, Jian, Cui, Jianhai, Zhang, Wei, Liu, Yunkui
Format: Artikel
Sprache:eng
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Zusammenfassung:A unique method for AgNO2-mediated direct nitration of the quinoxaline tertiary C-H bond and direct conversion of 2-methyl quinoxalines into 2-quinoxaline nitriles under oxidative conditions has been developed. This protocol provides an efficient way to access quinoxaline containing nitroalkanes and nitriles depending on different substrate selection.
ISSN:1364-548X
DOI:10.1039/c4cc01327a