Adhesion Forces between Lewis(X) Determinant Antigens as Measured by Atomic Force Microscopy

Adhesion Forces between Lewis(X) Determinant Antigens as Measured by Atomic Force Microscopy

The adhesion forces between individual molecules of Lewis(X) trisaccharide antigen (Le(X) ) have been measured in water and in calcium solution by using atomic force microscopy (AFM, see graph). These results demonstrate the self-recognition capability of this antigen, and reinforce the hypothesis t...

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Veröffentlicht in:Angewandte Chemie International Edition 2001-01, Vol.40 (16), p.3052-3055
Hauptverfasser: Tromas, C, Rojo, J, de la Fuente, J M, Barrientos, A G, García, R, Penadés, S
Format: Artikel
Sprache:eng
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Zusammenfassung:The adhesion forces between individual molecules of Lewis(X) trisaccharide antigen (Le(X) ) have been measured in water and in calcium solution by using atomic force microscopy (AFM, see graph). These results demonstrate the self-recognition capability of this antigen, and reinforce the hypothesis that carbohydrate-carbohydrate interaction could be considered as the first step in the cell-adhesion process in nature.
ISSN:1433-7851
DOI:10.1002/1521-3773(20010817)40:16<3052::AID-ANIE3052>3.0.CO;2-Q