Isolation and properties of Ca super(2+)-transporting glycoprotein and peptide from beef heart mitochondria

Isolation and properties of Ca super(2+)-transporting glycoprotein and peptide from beef heart mitochondria

The 40,000-dalton glycoprotein and 2000-dalton peptide inducing selective Ca super(2+)-transport through bilayer lipid membranes were isolated from beef heart homogenate and mitochondria. Micromolar concentrations of these substances were found to increase the conductivity of membranes by 3-4 orders...

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Veröffentlicht in:Journal of bioenergetics and biomembranes 1982-01, Vol.14 (4), p.213-226
Hauptverfasser: Mironova, G D, Sirota, T V, Pronevich, LA, Trofimenko, N V, Mironov, G P, Grigorjev, P A, Kondrashova, M N
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Sprache:eng
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Zusammenfassung:The 40,000-dalton glycoprotein and 2000-dalton peptide inducing selective Ca super(2+)-transport through bilayer lipid membranes were isolated from beef heart homogenate and mitochondria. Micromolar concentrations of these substances were found to increase the conductivity of membranes by 3-4 orders. Transmembrane Ca super(2+) gradient induces an electric potential difference whose magnitude is close to the theoretical for ideal Ca super(2+) selectivity.
ISSN:0145-479X