Structures of two novel toxins from Protogonyaulax

Structures of two novel toxins from Protogonyaulax

Saxitoxin and several other potent neurotoxins have been isolated from shellfish and dinoflagellates of the genus Protogonyaulax . The authors have recently described a novel class of related substances, significant in that they have relatively low in vivo toxicity until they are hydrolyzed to the p...

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Veröffentlicht in:Journal of the American Chemical Society 1981-11, Vol.103 (23), p.6977-6978
Hauptverfasser: Wichmann, Carol Fix, Niemczura, Walter P, Schnoes, Heinrich K, Hall, Sherwood, Reichardt, Paul B, Darling, Stephen D
Format: Artikel
Sprache:eng
Schlagworte:
Marine
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Zusammenfassung:Saxitoxin and several other potent neurotoxins have been isolated from shellfish and dinoflagellates of the genus Protogonyaulax . The authors have recently described a novel class of related substances, significant in that they have relatively low in vivo toxicity until they are hydrolyzed to the previously known toxins, and have now established the structures of two of these as carbamoyl-N-sulfo-11 alpha -hydroxysaxitoxin sulfate and the 11 beta -epimer.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00413a042