ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2014-05, Vol.46 (5), p.421-422
Hauptverfasser:	Zadeh, Gelareh, Aldape, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1922 Activin Receptors, Type I - genetics Agriculture Animal Genetics and Genomics Animals Astrocytoma - genetics Biomedicine Brain Neoplasms - genetics Brain Stem Neoplasms - genetics Cancer Research Families & family life Gene Expression Regulation, Neoplastic - genetics Gene Function Gene mutations Genes Genetic aspects Genetic research Genome, Human - genetics Genomes Genomics Glioma - genetics Gliomas Health aspects Human Genetics Humans Kinases Mutation Mutation - genetics Mutation, Missense - genetics news-and-views Pediatrics Phosphorylation Signal Transduction - genetics Studies Tumors Tumors in children
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Beschreibung
Zusammenfassung:	Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.2970