$Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia$

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

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Veröffentlicht in:	Leukemia 2014-07, Vol.28 (7), p.1545-1548
Hauptverfasser:	Matsuda, K, Nakazawa, Y, Iwashita, C, Kurata, T, Hirabayashi, K, Saito, S, Tanaka, M, Yoshikawa, K, Yanagisawa, R, Sakashita, K, Sasaki, S, Honda, T, Koike, K
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Mercaptopurine 631/208/737 631/67/1059 631/80/86 692/699/1541/1990/283 Cancer Research Cancer therapies Care and treatment Chemotherapy Child, Preschool Critical Care Medicine Drug Resistance, Neoplasm - genetics Female Gene mutations Genetic aspects Hematology Humans Identification and classification Infant Intensive Internal Medicine Kinases letter-to-the-editor Letters to the editor Leukemia Leukemia in children Leukemia, Myelomonocytic, Juvenile - drug therapy Leukemia, Myelomonocytic, Juvenile - genetics Leukemia, Myelomonocytic, Juvenile - metabolism Male Medicine Medicine & Public Health Mercaptopurine Mercaptopurine - pharmacology Mercaptopurine - therapeutic use Mutation Myelomonocytic leukemia Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oncology Patients Pharmaceuticals Properties Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Signal Transduction Toxicity Treatment Outcome
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ISSN:	0887-6924 1476-5551
DOI:	10.1038/leu.2014.58