Immunogenicity of a three dose and five dose oral human rotavirus vaccine (RIX4414) schedule in south Indian infants

Highlights • Study comparing immunogenicity of 3 and 5 doses of a monovalent oral rotavirus vaccine. • High rates (>50%) of anti-rotavirus IgA in 6 week old Indian infants pre-immunization. • Low seroconversion rates with no differences between 3- and 5-dose arms. • Among vaccine responders, chil...

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Veröffentlicht in:	Vaccine 2014-08, Vol.32, p.A129-A133
Hauptverfasser:	Kompithra, Rajeev Zachariah, Paul, Anu, Manoharan, Divya, Babji, Sudhir, Sarkar, Rajiv, Mathew, Leni G, Kang, Gagandeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Antibodies, Viral - blood Developing countries Diarrhea Gastroenteritis - prevention & control Gastroenteritis - virology Human rotavirus Humans Immunization Schedule Immunogenicity Immunoglobulin A - blood India Infant Infants Infections LDCs Rotavirus Infections - prevention & control Rotavirus vaccine Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - immunology Sample size Studies Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Viruses
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Beschreibung
Zusammenfassung:	Highlights • Study comparing immunogenicity of 3 and 5 doses of a monovalent oral rotavirus vaccine. • High rates (>50%) of anti-rotavirus IgA in 6 week old Indian infants pre-immunization. • Low seroconversion rates with no differences between 3- and 5-dose arms. • Among vaccine responders, children seropositive at baseline had higher increase in IgA than children seronegative at baseline.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.03.002