Synthetic aminomethylnaphthoquinones inhibit the in vitro replication of bovine herpesvirus 5
Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might b...
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| Veröffentlicht in: | Archives of virology 2014-07, Vol.159 (7), p.1827-1833 |
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| container_title | Archives of virology |
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| creator | Pinto, Ana Maria V Leite, José Paulo G Neves, Amanda P da Silva, Gustavo B Vargas, Maria D Paixão, Izabel Christina N. P |
| description | Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might be acting. The most potent and selective inhibitor exhibited CC₅₀ and EC₅₀ values of 1867 μM ± 8.3 and 3.8 μM ± 1.2, respectively (ACV: 989 μM ± 2 and 166 μM ± 2, respectively). |
| doi_str_mv | 10.1007/s00705-014-1989-3 |
| format | Article |
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The most potent and selective inhibitor exhibited CC₅₀ and EC₅₀ values of 1867 μM ± 8.3 and 3.8 μM ± 1.2, respectively (ACV: 989 μM ± 2 and 166 μM ± 2, respectively).</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-014-1989-3</identifier><identifier>PMID: 24493066</identifier><language>eng</language><publisher>Vienna: Springer-Verlag</publisher><subject>Acyclovir - pharmacology ; Animals ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Bovine herpesvirus 1 ; Bovine herpesvirus 5 ; Brief Report ; Cattle ; Cell Line ; Cytotoxicity ; Dogs ; Dose-Response Relationship, Drug ; Herpes viruses ; Herpesvirus ; Herpesvirus 5, Bovine - drug effects ; Herpesvirus 5, Bovine - physiology ; Infectious Diseases ; Medical Microbiology ; meningoencephalitis ; Molecular Structure ; Naphthoquinones - chemistry ; Naphthoquinones - pharmacology ; Viral Plaque Assay ; Virology ; Virus Replication - drug effects</subject><ispartof>Archives of virology, 2014-07, Vol.159 (7), p.1827-1833</ispartof><rights>Springer-Verlag Wien 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-30a0e78885b915840a09e39f92815c9c1d2b4a5423eb845200480c485a7844713</citedby><cites>FETCH-LOGICAL-c499t-30a0e78885b915840a09e39f92815c9c1d2b4a5423eb845200480c485a7844713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-014-1989-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-014-1989-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24493066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto, Ana Maria V</creatorcontrib><creatorcontrib>Leite, José Paulo G</creatorcontrib><creatorcontrib>Neves, Amanda P</creatorcontrib><creatorcontrib>da Silva, Gustavo B</creatorcontrib><creatorcontrib>Vargas, Maria D</creatorcontrib><creatorcontrib>Paixão, Izabel Christina N. 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| ispartof | Archives of virology, 2014-07, Vol.159 (7), p.1827-1833 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acyclovir - pharmacology Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Biomedical and Life Sciences Biomedicine Bovine herpesvirus 1 Bovine herpesvirus 5 Brief Report Cattle Cell Line Cytotoxicity Dogs Dose-Response Relationship, Drug Herpes viruses Herpesvirus Herpesvirus 5, Bovine - drug effects Herpesvirus 5, Bovine - physiology Infectious Diseases Medical Microbiology meningoencephalitis Molecular Structure Naphthoquinones - chemistry Naphthoquinones - pharmacology Viral Plaque Assay Virology Virus Replication - drug effects |
| title | Synthetic aminomethylnaphthoquinones inhibit the in vitro replication of bovine herpesvirus 5 |
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