Synthetic aminomethylnaphthoquinones inhibit the in vitro replication of bovine herpesvirus 5

Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might b...

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Veröffentlicht in:	Archives of virology 2014-07, Vol.159 (7), p.1827-1833
Hauptverfasser:	Pinto, Ana Maria V, Leite, José Paulo G, Neves, Amanda P, da Silva, Gustavo B, Vargas, Maria D, Paixão, Izabel Christina N. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - pharmacology Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Biomedical and Life Sciences Biomedicine Bovine herpesvirus 1 Bovine herpesvirus 5 Brief Report Cattle Cell Line Cytotoxicity Dogs Dose-Response Relationship, Drug Herpes viruses Herpesvirus Herpesvirus 5, Bovine - drug effects Herpesvirus 5, Bovine - physiology Infectious Diseases Medical Microbiology meningoencephalitis Molecular Structure Naphthoquinones - chemistry Naphthoquinones - pharmacology Viral Plaque Assay Virology Virus Replication - drug effects
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Zusammenfassung:	Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might be acting. The most potent and selective inhibitor exhibited CC₅₀ and EC₅₀ values of 1867 μM ± 8.3 and 3.8 μM ± 1.2, respectively (ACV: 989 μM ± 2 and 166 μM ± 2, respectively).
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-014-1989-3