Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis

We compared analgesic activities of individual alkaloids extracted from Baikal aconite ( Aconitum baikalensis ): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were di...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-08, Vol.157 (4), p.488-491
Hauptverfasser:	Nesterova, Yu. V., Povet’yeva, T. N., Suslov, N. I., Zyuz’kov, G. N., Pushkarskii, S. V., Aksinenko, S. G., Schultz, E. E., Kravtsova, S. S., Krapivin, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid Aconitine - analogs & derivatives Aconitine - isolation & purification Aconitine - pharmacology Aconitum - chemistry Alkaloids Alkaloids - isolation & purification Alkaloids - pharmacology Analgesics Analgesics - isolation & purification Analgesics - pharmacology Animals Animals, Outbred Strains Arthritis, Experimental - chemically induced Arthritis, Experimental - physiopathology Biomedical and Life Sciences Biomedicine Cell Biology Dipyrone - pharmacology Freund's Adjuvant Injections, Intraperitoneal Internal Medicine Laboratory Medicine Mice Pain - chemically induced Pain - physiopathology Pain - prevention & control Pathology Plant Extracts - chemistry Rats Seizures - chemically induced Seizures - physiopathology Seizures - prevention & control Vocalization, Animal - drug effects
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Zusammenfassung:	We compared analgesic activities of individual alkaloids extracted from Baikal aconite ( Aconitum baikalensis ): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2598-6