Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway
Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the e...
Gespeichert in:
| Veröffentlicht in: | Environmental toxicology and pharmacology 2014-07, Vol.38 (1), p.163-171 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 171 |
|---|---|
| container_issue | 1 |
| container_start_page | 163 |
| container_title | Environmental toxicology and pharmacology |
| container_volume | 38 |
| creator | Li, Daotong Ma, Haoran Ye, Yaqiong Ji, Changyun Tang, Xiaohong Ouyang, Dan Chen, Jian Li, Yugu Ma, Yongjiang |
| description | Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the expression levels of apoptosis-associated proteins in MTEC1 cells. |
| doi_str_mv | 10.1016/j.etap.2014.05.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554472174</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1382668914001409</els_id><sourcerecordid>1554472174</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-2b64114685e543a102882213c52e608dd7c3c05806852ddb5eef26c1df91f6163</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS1ERcvAH2CBsmST4HcyEkJC5SlV6gJYWx77pvHgxMF22ubf42gKCxZdXevq3COf7yD0iuCGYCLfHhvIem4oJrzBosFEPEEXpGtp3eK2fVrerKO1lN3-HD1P6YiLgrHuGTqnfC8o4_wC3XyEcL9O7lZ7mIKv3GQXA6nSc5hzSC6VTTWGJUGVh3V0poLZ5QG8074y4H0q-xiWm6EaXQ5mCJONTtcjWKcz2GrWebjT6wt01muf4OXD3KGfnz_9uPxaX11_-Xb54ao2nJBc04Msk8tOgOBME0y7jlLCjKAgcWdta5jBosNFQa09CICeSkNsvye9JJLt0JuT7xzD7wVSVqNL2z_1BCWFIkJw3lLS8iKlJ6mJIaUIvZqjG3VcFcFqA6yOagOsNsAKC7Xh26HXD_7LoWT8d_KXaBG8OwmgpLx1EFUyDiZTeEQwWdngHvd__9-58W5yRvtfsEI6hiVOhZ8iKlGF1fet4q1hwku7HO_ZHwipopQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1554472174</pqid></control><display><type>article</type><title>Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Li, Daotong ; Ma, Haoran ; Ye, Yaqiong ; Ji, Changyun ; Tang, Xiaohong ; Ouyang, Dan ; Chen, Jian ; Li, Yugu ; Ma, Yongjiang</creator><creatorcontrib>Li, Daotong ; Ma, Haoran ; Ye, Yaqiong ; Ji, Changyun ; Tang, Xiaohong ; Ouyang, Dan ; Chen, Jian ; Li, Yugu ; Ma, Yongjiang</creatorcontrib><description>Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the expression levels of apoptosis-associated proteins in MTEC1 cells.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2014.05.015</identifier><identifier>PMID: 24952344</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Caspases - metabolism ; Cell Line ; Deoxynivalenol ; Emergency ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Epithelial Cells - physiology ; Membrane Potential, Mitochondrial - drug effects ; Mice ; Mitochondria - drug effects ; Mitochondria - physiology ; Mitochondrial ; MTEC1 cells ; P53 ; Poly(ADP-ribose) Polymerases - metabolism ; Reactive Oxygen Species - metabolism ; ROS ; Thymus Gland - cytology ; Trichothecenes - toxicity ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Environmental toxicology and pharmacology, 2014-07, Vol.38 (1), p.163-171</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-2b64114685e543a102882213c52e608dd7c3c05806852ddb5eef26c1df91f6163</citedby><cites>FETCH-LOGICAL-c411t-2b64114685e543a102882213c52e608dd7c3c05806852ddb5eef26c1df91f6163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etap.2014.05.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24952344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Daotong</creatorcontrib><creatorcontrib>Ma, Haoran</creatorcontrib><creatorcontrib>Ye, Yaqiong</creatorcontrib><creatorcontrib>Ji, Changyun</creatorcontrib><creatorcontrib>Tang, Xiaohong</creatorcontrib><creatorcontrib>Ouyang, Dan</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Li, Yugu</creatorcontrib><creatorcontrib>Ma, Yongjiang</creatorcontrib><title>Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the expression levels of apoptosis-associated proteins in MTEC1 cells.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Caspases - metabolism</subject><subject>Cell Line</subject><subject>Deoxynivalenol</subject><subject>Emergency</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - physiology</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Mice</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - physiology</subject><subject>Mitochondrial</subject><subject>MTEC1 cells</subject><subject>P53</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>ROS</subject><subject>Thymus Gland - cytology</subject><subject>Trichothecenes - toxicity</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS1ERcvAH2CBsmST4HcyEkJC5SlV6gJYWx77pvHgxMF22ubf42gKCxZdXevq3COf7yD0iuCGYCLfHhvIem4oJrzBosFEPEEXpGtp3eK2fVrerKO1lN3-HD1P6YiLgrHuGTqnfC8o4_wC3XyEcL9O7lZ7mIKv3GQXA6nSc5hzSC6VTTWGJUGVh3V0poLZ5QG8074y4H0q-xiWm6EaXQ5mCJONTtcjWKcz2GrWebjT6wt01muf4OXD3KGfnz_9uPxaX11_-Xb54ao2nJBc04Msk8tOgOBME0y7jlLCjKAgcWdta5jBosNFQa09CICeSkNsvye9JJLt0JuT7xzD7wVSVqNL2z_1BCWFIkJw3lLS8iKlJ6mJIaUIvZqjG3VcFcFqA6yOagOsNsAKC7Xh26HXD_7LoWT8d_KXaBG8OwmgpLx1EFUyDiZTeEQwWdngHvd__9-58W5yRvtfsEI6hiVOhZ8iKlGF1fet4q1hwku7HO_ZHwipopQ</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Li, Daotong</creator><creator>Ma, Haoran</creator><creator>Ye, Yaqiong</creator><creator>Ji, Changyun</creator><creator>Tang, Xiaohong</creator><creator>Ouyang, Dan</creator><creator>Chen, Jian</creator><creator>Li, Yugu</creator><creator>Ma, Yongjiang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway</title><author>Li, Daotong ; Ma, Haoran ; Ye, Yaqiong ; Ji, Changyun ; Tang, Xiaohong ; Ouyang, Dan ; Chen, Jian ; Li, Yugu ; Ma, Yongjiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-2b64114685e543a102882213c52e608dd7c3c05806852ddb5eef26c1df91f6163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Caspases - metabolism</topic><topic>Cell Line</topic><topic>Deoxynivalenol</topic><topic>Emergency</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelial Cells - physiology</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Mice</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - physiology</topic><topic>Mitochondrial</topic><topic>MTEC1 cells</topic><topic>P53</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>ROS</topic><topic>Thymus Gland - cytology</topic><topic>Trichothecenes - toxicity</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Daotong</creatorcontrib><creatorcontrib>Ma, Haoran</creatorcontrib><creatorcontrib>Ye, Yaqiong</creatorcontrib><creatorcontrib>Ji, Changyun</creatorcontrib><creatorcontrib>Tang, Xiaohong</creatorcontrib><creatorcontrib>Ouyang, Dan</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Li, Yugu</creatorcontrib><creatorcontrib>Ma, Yongjiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Daotong</au><au>Ma, Haoran</au><au>Ye, Yaqiong</au><au>Ji, Changyun</au><au>Tang, Xiaohong</au><au>Ouyang, Dan</au><au>Chen, Jian</au><au>Li, Yugu</au><au>Ma, Yongjiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>38</volume><issue>1</issue><spage>163</spage><epage>171</epage><pages>163-171</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>Highlights • Deoxynivalenol (DON) can induce apoptosis in mouse thymic epithelial cell line 1 (MTEC1). • DON can increase the protein levels of p53 in MTEC1 cells. • DON can increase reactive oxygen species levels and decrease mitochondrial membrane potential in MTEC1 cells. • DON can increase the expression levels of apoptosis-associated proteins in MTEC1 cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24952344</pmid><doi>10.1016/j.etap.2014.05.015</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2014-07, Vol.38 (1), p.163-171 |
| issn | 1382-6689 1872-7077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1554472174 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Apoptosis Apoptosis - drug effects Caspases - metabolism Cell Line Deoxynivalenol Emergency Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - physiology Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - physiology Mitochondrial MTEC1 cells P53 Poly(ADP-ribose) Polymerases - metabolism Reactive Oxygen Species - metabolism ROS Thymus Gland - cytology Trichothecenes - toxicity Tumor Suppressor Protein p53 - metabolism |
| title | Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A45%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deoxynivalenol%20induces%20apoptosis%20in%20mouse%20thymic%20epithelial%20cells%20through%20mitochondria-mediated%20pathway&rft.jtitle=Environmental%20toxicology%20and%20pharmacology&rft.au=Li,%20Daotong&rft.date=2014-07-01&rft.volume=38&rft.issue=1&rft.spage=163&rft.epage=171&rft.pages=163-171&rft.issn=1382-6689&rft.eissn=1872-7077&rft_id=info:doi/10.1016/j.etap.2014.05.015&rft_dat=%3Cproquest_cross%3E1554472174%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1554472174&rft_id=info:pmid/24952344&rft_els_id=1_s2_0_S1382668914001409&rfr_iscdi=true |